Cybernetic cloning - a biologist's view
by
POULAMI MITRA
School Medicine,
University of Pittsburgh
Pennsylvania (USA)
Great minds have always been intrigued by the inherent complexity
and diversity in the life process. We are living in a time
where the understanding of mysteries of Nature is expanding
at an explosive pace. The ultimate goal in science is to decipher
the mysteries of Nature and Life, and the different paths to
do so are called by different names like Physics, Mathematics,
Biology, etc. Biological systems largely rest on a holistic
approach, adhering by the principles of physics, chemistry and
mathematics and for that matter all possible logistic sciences.
Physics, characterized by uniformity and generality, is a strongly
reductionistic science and has significantly prospered in this
way. Based on the assumptions of simplicity and with the aid
of mathematical formulations, physics attempts to understand
biological phenomena, with the presumption that complex systems
have underlying simple laws. As a result, biological sciences
also suffer from permeation by mechanistic reductionism in the
guise of two metaphors : (1) the dynamic metaphor of
organisms as machines and (2) the information metaphor
of life as a blueprint on DNA.
Firstly let us consider the dynamic metaphor of treating life
as a 'machine'. Machine runs on the basis of physical
laws, precisely on Newtonian dynamics. The difficulty of applying
the simple machine model to biological systems is more than
one. Firstly, organisms are of intermediate size and cannot
be treated as particles. Secondly, they are internally heterogeneous,
meaning that their state of motion or normalcy is determined
by a multiplicity of interacting individual causal chains of
influences. Thirdly, these individual heterogeneous systems
enter into complex causal relations with other heterogeneous
systems. All these make it difficult for us to separate causes
from effects, So, in biology we land up having causal explanations,
whereas in physics we have generalizations of the behavior
of objects, such as Kepler's laws of planetary movements.
The
concept of feeding loops has now firmly entered into the treatment
of physical systems as a result of the development of cybernetic
and control theory. Cybernetics or the principle of 'controls'
has been applied to biology, where regulation and feedback are
the criteria for normalcy. The importance of control system
engineering lies in determining operating conditions and stability
of the mechanical models. A system requires stability through
feedback mechanisms. Consider a servo motor which employs the
principle of negative feedback to stabilize gain and frequency
responses. Feedback essentially consists of' feeding a part
of the output back to the input to determine error conditions
and also to detect whether the desired output has been reached,
within the specific tolerance level.
Now let us take ap a simple example to consider what happens
when biological systems are modeled according to system analysis.
Consider a cell and its environment. The external conditions
imposed on the cell are the ‘inputs’ as in mechanical models
and the cell responses are same as 'outputs' : the cell also
maintains feeback loops to attain dynamic equilibrium with the
environment. We must remember that apart from changes going
on with the cell changes are incessantly occurring in the environment
as well. So, we have two systems interacting with each other
with the goal of establishing a dynamic equilibrium state. Scrutiny
reveals that in the case of cell an its environment we are actually
being unable to decide where to place the reference frame :
whether in the cell or in the environment. In other words, the
biological system is non-Newtonian. Again, to develop nuemerical
methods of analysis for this biological model we will have continuously
changing transfer functions from the output to the input that
will lead to ‘varying stability criteria’. The number of iteration
(such as temperature, pressure, pH etc.) therefore required
would be too large to handle. This will lead to formulation
of what is called in mechanistic terms ‘inexact differentials’
that is, there will always remain a factor that will vary from
state to state thereby jeopardizing the aim of establishing
a set format.
Another aspect of biology that gets gainsaid in consideration
of the machine model is that organisms have a history.
This history is at two levels: the individual life stories that
began with a single fertilized ovum a collective history that
started billions of years ago when proteins gelled together
into ‘living’ protoplasm. The designers of modern cars do not
have to consult Diamler’s origin design for an internal combustion
engine, whereas, the problem of brain function in perception
and memory is precisely the problem of how the neural connections
come to be formed under the influence of sights, sound, caresses
and blows.
Let its now consider the second metaphor for life, that is
‘information metaphor, according to which genomic DNA
contains the information for all life processes of an individual.
The constant reiteration of the claims that genes determine
organism is consequence the ease with which major genetic changes
can be induced experimentally and large effects that these changes
have on experimental objects. A closer look reveals those phenomena
are considered that lend themselves. The DNA sequence alone
cannot tell us what organism will look like, except in general
terms. It is, on the other hand, determined an intricate play
of the genes, the environment and the organism
itself. Development is not simply the realization of an internal
program (transcription and translation of DNA) but the outside
also matters. Stage theories in developmental processes very
clearly prove this point in the process of embryonic development
to the ‘2 cell stage’ to ‘4 cell stage’ to ‘blastocyst’, an
embryo may get stuck at any intermediate stage : the problem
might be internal or external. The tropical vine will never
switch (dictated by genes) from a creeper state to a climber
state unless it encounters a trunk (the environment). Organisms
are therefore a result of both its genes and the temporal sequence
of environments through which it has passed.
Nature poses problems that the organism must solve or perish.
The internal make up of the organism tries to solve these problems
imposed by the external world by way of say random mutation
and evolution of the species occurs. The organism thus becomes
the passive nexus of internal and external forces. The organism
is nevertheless considered important because it is impossible
to judge the problems posed by Nature without describing the
organism for which the problem exists. Again, we cannot characterize
the environment except in the presence of the organism that
it surrounds. So, by and large, it is an intricate complex
and non-linear interaction of genes, environment and the organism
that will determine a pattern.
We should thus realize that simplicity in biological functional
order is an exception and complexity is the rule. We must accept
that there lies many aspects of nonreducibility at the core
of all life's beauty, that man is yet to comprehend and then
only he may cybernetically clone life.