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Original Article
66 (
); 126-130

Blood pressure trend of lowlanders during first 6 days of acclimatisation to high altitude

Department of Physiology, Defence Institute of Physiology and Allied Sciences, New Delhi, India
Department of Physiology, Armed Forces Medical College, Pune, Maharashtra, India
Department of Internal Medicine, Armed Forces Medical College, Pune, Maharashtra, India
Department of Internal Medicine, Armed Forces Clinic, New Delhi, India
Department of Community Medicine, Armed Forces Medical College, Pune, Maharashtra, India
Department of Emergency Medicine, Military Hospital Leh, Ladakh, Jammu and Kashmir, India
Corresponding author: Dr. Krishan Singh, Department of Physiology, Defence Institute of Physiology and Allied Sciences, New Delhi, India.
This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, transform, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

How to cite this article: Singh K, Shekhar A, Singh SK, Kumar R, Yadav AK, Manimaran P, et al. Blood pressure trend of lowlanders during first 6 days of acclimatisation to high altitude. Indian J Physiol Pharmacol 2022;66:126-30.



The present study was planned to delineate the blood pressure (BP) response of the lowlanders during initial 6 days of acclimatisation to high altitude.

Materials and Methods:

398 normotensive sojourners at sea level ascended to HA (3,500 m). Blood pressure response of these subjects were analysed for 6 consecutive days at HA. Based on the BP response of these subjects on the 6th day at HA they were divided into two groups: HBP-high BP group and NBP- normal BP group.


It showed that on 6th day at HA, 51 out of 398 subjects presented with BP≥140/90 mmHg (HBP) while others remained normotensive (NBP). Comparative systolic BP of HBP and NBP groups during successive days at HA were as follows: HA day 1 (146.8 ± 13.7 mmHg vs 146.3 ± 8.8 mmHg, p>0.05), HA day 4 (144.5 ± 8.7 mmHg vs 135.0 ± 7.0 mmHg, p<0.05) and HA day 6 (148.1 ± 7.9 mmHg vs 131.7 ± 5.3 mmHg, p<0.05). Whereas, diastolic BP of HBP and NBP groups were: HA day 1 (94.0 ± 8.1 mmHg vs 93.2 ± 6.6 mmHg, p>0.05), HA day 4 (88.9 ± 6.0 mmHg vs 85.3 ± 5.1 mmHg, p<0.05) and HA day 6 (93.8 ± 6.3 mmHg vs 83.7 ± 3.8 mmHg, p<0.05).


It was found that NBP had initially raised BP which returned to normal levels after acclimatisation period of 6 days, but in HBP, it started rising after 4th day. It can be concluded that those individuals whose BP on 6th day at HA does not return to normal after acclimatisation period needs regular follow up as these individuals can have a delayed acclimatisation normalising BP later on or can become hypertensive subsequently.


High altitude
High altitude systemic hypertension


Low barometric pressure at high altitude (HA) lowers the alveolar oxygen in human sojourns in these areas. This hypobaric hypoxia stimulates oxygen sensitive chemoreceptors in the carotid body and the brainstem resulting in an increased efferent sympathetic outflow.[1,2] The sustained activation of sympathetic nervous system ensures oxygen supply to cells and tissues by increasing heart rate and cardiac output.[3] Subsequently, the acclimatisation process partially restores arterial oxygen content thereby reducing sympathoexcitatory chemoreceptor drive. Despite this normalisation, some healthy humans exhibit increased systemic arterial pressure irrespective of the hypoxia exposure duration.[4]

It is observed that the normotensive individuals at sea level frequently end up with hypertension when exposed to HA stress. This hypoxic stress aggravates the 24-h ambulatory systolic, diastolic, day time and night time blood pressure of individuals, in both normotensive as well as hypertensive.[5] This augmentation of BP in hypertensive individuals is more pronounced; hence, poorly controlled hypertensives are advised to refrain from travel to HA. Various investigations have demonstrated differing impacts of BP in response to HA in normotensive subjects. Studies in healthy individuals without hypertension have either shown increase, decrease, or no change in BP at HA.[5-7] It is important to note that effect of HA on BP is inadequately characterised. Some studies have associated modified sympathoadrenal activity for systemic hypertension at HA.[8,9]

One of the intriguing findings is that normotensives who develop hypertension at HA revert to normal values on returning to sea level. Such type of hypertension has been arbitrarily labelled as HA systemic hypertension. This is of significance in case of people who spend a longer tenure at HA like soldiers and mine workers. Hypertension in such individuals regularly faces the repercussion of increased BP and is frequently put on antihypertensive medication.

It has been seen that hypoxia of HA increases BP and also an appreciable number of lowlanders who stay at HA for longer time develop systemic hypertension. The present study was hence planned to delineate the BP response of the lowlanders during initial days of acclimatisation to HA.



An observational and cohort study was conducted at two transit camps located at sea level (altitude 321 m) and at an altitude of 3500 m, during December 2018–April 2019. A total of 500 Indian male soldiers initially became a part of the study but data collection could be completed for 398 subjects. Inclusion criteria were age more than 20 years and BP <140/90 mmHg at sea level. Exclusion criteria were: (1) Smoking (2) chronic diseases such as diabetes, chronic kidney or liver disease and (3) on any long-term medication. Sea level data served as baseline values of these subjects. The approval of study protocols was taken from the Institutional Ethics Committee and informed written consent was obtained from all the subjects.

BP measurements

BP measurements were made on the right-hand supine using calibrated mercury sphygmomanometers by trained nurses. Three readings were taken at an interval of 5 min after relaxing for 5 min and subject was lying quietly and arm at the heart level. Average of three readings was taken as the BP value. Every time, one dedicated nurse use to measure BP at sea level and HA. Systolic BP (SBP) was defined by the appearance of first Korotkoff sound whereas diastolic BP (DBP) by fifth Korotkoff sound (disappearance of sound). Mercury manometers were chosen as they are not influenced by altitude. Normal BP (NBP) was considered BP <140/90 mm Hg called NBP group and high BP (HBP) was > 140/90 mm Hg – HBP group.[10,11]

HA measurements

For HA, subjects were taken to Leh, Ladakh (3500 m), India by air induction and BP of these subjects was monitored for 6 consecutive days. All the subjects received same fixed diet and performed comparable exercise during the whole investigation time frame. The subjects were refrained from taking any medication of their own like acetazolamide or dexamethasone.

Statistical analysis

Continuous variable was presented as mean and standard deviation. Categorical was described as number and percentage. Repeated measure ANOVA was done for repeated SBP, DBP and mean BP (MBP) over a period of days. Repeated measures mixed model using REML was used to adjust for age and body mass index (BMI). StataCorp. 2019. Stata Statistical Software: Release 16. College Station, TX: StataCorp LLC. P < 0.05 was considered significant.


Data were collected from 398 participants out of 500 participants eligible during the study period. The physical characteristics of the participants are shown in [Table 1].

Table 1:: Physical characteristics of participants.
Age 31.5±6.4 Yrs
Weight 68.8±8.4 Kg
Height 1.7±0.1 m
BMI 23.2±2.5 kg/m2
SBP at Sea Level 123.3±8.5
BP at Sea Level 79.2±5.8

Values are presented as Mean±SD

At HA out of 398 participants on 6th day, 51 (12.8% [95% CI: 9.6–16.5]) had BP more than 140/90 mmHg and 347 had BP <140/90 mmHg. The pattern of change of BP over time is shown in [Figure 1].

Figure 1:: Pattern of change in blood pressure at different days at high altitude.

On HA day 1, both the groups exhibited significantly increased BP from sea level (SL) and on HA day 4, HBP group showed significantly higher BP than NBP group SBP (144.5 ± 8.7 mmHg vs. 135.0 ± 7.0 mmHg, P < 0.05) and DBP (88.9 ± 6.0 mmHg vs. 85.3 ± 5.1 mmHg, P < 0.05). Similarly, on HA day 6, HBP group showed significantly higher BP than NBP group SBP (148.1 ± 7.9 mmHg vs. 131.7 ± 5.3 mmHg, P < 0.05) and DBP (93.8 ± 6.3 mmHg vs. 83.7 ± 3.8 mmHg, P < 0.05) [Table 2].

Table 2:: Change in BP over period of time at high altitude.
NBP group (347) 146.3 (8.8) 141.5 (8.8) 137.4 (9.1) 135 (7) 132.8 (8.5) 131.7 (5.3) <0.001
HBP group (51) 146.8 (13.7) 144.2 (8.9) 142.9 (9.6) 144.5 (8.7) 146.6 (11) 148.1 (7.9)
NBP group (347) 93.2 (6.6) 89.2 (8) 87.4 (5.4) 85.3 (5.1) 84.9 (4.5) 83.7 (3.8) <0.001
HBP group (51) 94 (8) 91.3 (6.8) 90.3 (5.8) 88.9 (6) 90.9 (5.8) 93.8 (6.3)
NBP group (347) 109.8 (6) 105.6 (7) 103 (5.5) 100.8 (5) 99.8 (4.5) 98.7 (3.7) <0.001
HBP group (51) 110.5 (9.1) 107.8 (6.6) 106.8 (6) 106.4 (5.9) 108.4 (6.1) 110.8 (5.4)

Values are mean (SD), SBP1 to SBP6 - Systolic BP at day 1 to day 6 HA, DBP1 to DBP6 - Diastolic BP at day 1 to day 6 HA, MBP1 to MBP6 - Mean BP at day 1 to day 6 HA, HA: High altitude, BP: Blood pressure, SBP: Systolic blood pressure, NBP: Normal blood pressure, HBP: High blood pressure, DBP: Diastolic blood pressure

There was a significant difference in BP values through the extent of time as well as between HBP and NBP group for SBP, DBP and MBP (Repeated Measurement ANOVA: P < 0.001 for all three measurements). Repeated measurement model using restricted maximum likelihood method was done for adjustment of the age and BMI. However, the difference among and within group remains significant [Table 3] as regard to systematic BP, similar findings have been shown for diastolic and MBP (Not Shown). In the two groups, the difference in blood pressure became statistically significant from fourth day onwards [Table 3].

Table 3:: Repeated measure mixed model for systolic blood pressure.
Characteristic Coefficient 95% Confidence Interval P-value
Day 1 Reference
Day 2 −3.99 −4.77-(−3.22) <0.001
Day 3 −5.80 −6.5–(−5.03) <0.001
Day 4 −7.90 −8.6–(−7.13) <0.001
Day 5 −8.33 −9.1–(−7.55) <0.001
Day 6 −9.48 −10.25–(−8.7) <0.001
Day 1 Reference
Day 2 1.27 −0.90– (3.43) 0.25
Day 3 2.12 −0.47–4.3 0.06
Day 4 2.84 0.68–5.01 0.01
Day 5 5.22 3.06–7.40 <0.001
Day 6 9.34 7.18–11.51 <0.001
Age 0.04 −0.018–0.09 0.19
BMI −0.067 −0.21–0.08 0.19

BMI: Body mass index

Mean MBP increased on 1st day of HA. The mean MBP decreased gradually for both HBP and NBP groups; however, for HBP, it started increasing on 4th day onwards at HA [Figure 2].

Figure 2:: Change in mean blood pressure on different days at high altitude.


The main finding of the present study is that the majority of the subjects had a continuous fall of BP during the days of acclimatisation making them normotensive whereas in others BP continuously increased 4th day onwards. The immediate effect of HA ascent is a decrease in BP by endothelium-dependent and endothelium-independent systemic vasodilation[12] but curiously our subjects did not show such instantaneous hypotensive impact of HA. This physiological response is counteracted by sympathetic vasoconstriction essentially by arterial hypoxemia after few hours of stay at HA. Peripheral chemoreceptors located in the carotid bodies and cardiovascular control regions of the mid-brain mediate hypoxia-induced vasoconstriction resulting in critical and steady increase in arterial BP.[13] In our study, there was increased BP on the 1st day at HA and this change was sustained over the first 3 days after which NBP group starts to come back to normal as acclimatisation sets in. In the HBP group, the increase was sustained and there was further increase. This was distinctly different from a study by Roach et al.,[14] in which the MBP of 64 normotensive and 33 older hypertensives was higher at 2500 m than recorded home measurements, but gradually diminished, stabilising on day 3. The present study observed this pattern in both the groups initially for 3 days but the HBP participants, started having higher BP from the 4th day onwards at HA and in NBP subjects BP continues to decline. Hence, on the 6th day at HA, BP reverted to normal indices (i.e., ≤140/90 mmHg) in the NBP group but persisted above 140/90 mmHg in the HBP group. The underlying mechanisms through which BP returns to near-normal or even lower values have been generally thought to be a part of the acclimatisation process. Despite the extant of the literature with regard to BP and acclimatisation timing, the period when continually exposed lowlanders achieves that acclimatisation is not well established,[3] and there are no such epidemiological studies.

The sustained high DBP and borderline SBP values observed in many subjects of our study group for a protracted period of time requires further investigation. The phenomenon could be a steady portrayal of sympathetic stimulation, though it is not yet known when it ceases.[3] Another factor playing a role in the elevation of BP in chronic hypoxia could also be an overstated reaction to enhanced chemoreceptor reflex described for hypertension prone individuals.[15] An increased blood viscosity[16] and alteration of the endothelial function[17] have likewise been implicated. Hence, a single factor will be insufficient to explain the phenomenon.

The increase of sympathetic tone might be a characteristic reaction to balance the impacts of hypoxia in case of nonacclimatised subjects. Hypoxia directly causes vasodilation and if acting through peripheral chemoreceptors leads to vasoconstriction through sympathetic stimulation.[18,19] Interactions occur between the hypoxic vasodilatation of systemic arterioles and the chemoreceptor-mediated responses in the systemic circulation.[20-22] This, thus prompts baroreceptor-mediated sympathetic excitation. Other varied reasons could be alterations in baroreflex function, an increase in the ‘set point’ and possibly a decrease in gain. These autonomic adjustments may have a role in an escalation in BP during sustained hypoxia.[22,23] Moreover, few data exist regarding the relative importance of other neurohormones such as angiotensin, aldosterone or vasopressin, all of which may be involved in some degree with raising BP during sustained high-altitude exposure.


This study included only male subjects hence the data cannot be generalised to both the genders. Those subjects who had HBP on the 6th day could have been monitored for future development of hypertension.


There was a contrasting BP response of individuals during acclimatisation on continual recording. The majority of the subjects could revert the BP back to normal levels after the initial rise while in few, BP remained elevated throughout. Hence, it can be concluded that few percentage of lowlanders remain with high BP after acclimatisation to HA. Such individuals should be monitored regularly after acclimatisation as these individuals can have a delayed acclimatisation normalising BP later on or can become hypertensive subsequently.


The authors acknowledge the support of Indian Army soldiers for giving their supporting in conducting the study.

Declaration of patient consent

Patient’s consent not required as there are no patients in this study.

Financial support and sponsorship


Conflicts of interest

There are no conflicts of interest.


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